Sigmund Freud is the father of psychoanalysis. He believed that we all repressed unwanted feelings and desires into our unconscious mind. He also developed a theory on how the human mind is organized and works internally. Most people are unaware that Freud suffered from panic attacks and showed symptoms of Anxiety Disorder. In all of his medical evaluations, all he was told is that his symptoms were simply of a nervous origin.
Sigmund Freud's panic attacks actually had a large impact on his career. When he was tired of what the doctor's were telling him, he decided to try and find a psychological reason for his panic attacks. He designed an entire psychological model to try and describe how the brain internalized and maintained anxiety. This became an important and well known aspect of his theories and applied directly to his ideas about the unconscious.
His work has changed how we think of psychology even though they have been mostly proven wrong. He was motivated by these attacks to work even harder on his work to help him understand his own problems.